Biomarkers in Breast Cancer Cancer Drug Discovery
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منابع مشابه
Identification of Prognostic Genes in Her2-enriched Breast Cancer by Gene Co-Expression Net-work Analysis
Introduction: HER2-enriched subtype of breast cancer has a worse prognosis than luminal subtypes. Recently, the discovery of targeted therapies in other groups of breast cancer has increased patient survival. The aim of this study was to identify genes that affect the overall survival of this group of patients based on a systems biology approach. Methods: Gene expression data and clinical infor...
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Introduction: Proliferation of cancer cells and the potential of metastasis depend on the activity of different biomarkers such as proliferative ones. Proliferative biomarkers including ki-67, cyclin E1, cyclin D1, p27, and p21 were analyzed through immunohistochemistry (IHC) in previous studies. Methods: The current study aimed at investigating the utilizing role of RT-PCR in studying prolife...
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Introduction: Proliferation of cancer cells and the potential of metastasis depend on the activity of different biomarkers such as proliferative ones. Proliferative biomarkers including ki-67, cyclin E1, cyclin D1, p27, and p21 were analyzed through immunohistochemistry (IHC) in previous studies. Methods: The current study aimed at investigating the utilizing role of RT-PCR in studying prolife...
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Despite diagnostic, preventive and therapeutic advances, growing incidence of cancer and high rate of mortality among patients affected by specific cancer types indicate current clinical measures are not ideally useful in eradicating cancer. Chemoresistance and subsequent disease relapse are believed to be mainly driven by the cell-molecular heterogeneity of human tumors that necessitates perso...
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تاریخ انتشار 2013